Rashba Iu E, Nagler L G, Vartanian L S, Oktiabr'skaia L A, Bilenko M V
Biull Eksp Biol Med. 1990 Jun;109(6):548-50.
While studying xanthine-xanthine oxidase system it was found, that a considerable accumulation of xanthine and uric acid occurred whereas xanthine dehydrogenase did not transfer in xanthine oxidase during 2 hours of total rat liver ischemia. These data make it possible to reject the generally accepted hypothesis of xanthine oxidase key role in free radical mechanism of ischemia damage.
在研究黄嘌呤-黄嘌呤氧化酶系统时发现，在大鼠肝脏完全缺血2小时期间，黄嘌呤和尿酸大量蓄积，而黄嘌呤脱氢酶并未转化为黄嘌呤氧化酶。这些数据使得人们有可能摒弃关于黄嘌呤氧化酶在缺血损伤自由基机制中起关键作用这一普遍接受的假说。
