用于研究鼠疫发病机制和开发新疗法的模型系统。
Model systems to study plague pathogenesis and develop new therapeutics.
作者信息
Lawrenz Matthew B
机构信息
Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Department of Microbiology and Immunology, University of Louisville School of Medicine Louisville, KY, USA.
出版信息
Front Microbiol. 2010 Nov 4;1:119. doi: 10.3389/fmicb.2010.00119. eCollection 2010.
Abstract
The Gram negative bacterium Yersinia pestis can infect humans by multiple routes to cause plague. Three plague pandemics have occurred and Y. pestis has been linked to biowarfare in the past. The continued risk of plague as a bioweapon has prompted increased research to understand Y. pestis pathogenesis and develop new plague therapeutics. Several in vivo models have been developed for this research and are reviewed here.
摘要
革兰氏阴性细菌鼠疫耶尔森菌可通过多种途径感染人类，引发鼠疫。历史上曾发生过三次鼠疫大流行，鼠疫耶尔森菌也曾被用于生物战。鼠疫作为一种生物武器持续存在的风险促使人们加大研究力度，以了解鼠疫耶尔森菌的致病机制并开发新的鼠疫治疗方法。为此研究已开发了多种体内模型，本文将对其进行综述。
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