Aminov Rustam I
Rowett Institute of Nutrition and Health, University of Aberdeen Aberdeen, UK.
Front Microbiol. 2010 Dec 8;1:134. doi: 10.3389/fmicb.2010.00134. eCollection 2010.
This article gives a very brief overview of the antibiotic era, beginning from the discovery of first antibiotics until the present day situation, which is marred by the emergence of hard-to-treat multiple antibiotic-resistant infections. The ways of responding to the antibiotic resistance challenges such as the development of novel strategies in the search for new antimicrobials, designing more effective preventive measures and, importantly, better understanding the ecology of antibiotics and antibiotic resistance are discussed. The expansion of conceptual frameworks based on recent developments in the field of antimicrobials, antibiotic resistance, and chemotherapy is also discussed.
本文简要概述了抗生素时代，从第一种抗生素的发现一直到当今的情况，如今面临着难以治疗的多重耐药感染的出现这一困境。文中讨论了应对抗生素耐药性挑战的方法，比如开发寻找新型抗菌药物的新策略、设计更有效的预防措施，以及尤为重要的是，更好地理解抗生素生态学和抗生素耐药性。此外，还讨论了基于抗菌药物、抗生素耐药性和化疗领域近期进展的概念框架的扩展。
