Department of Life Science, National Taitung University, Taitung, Taiwan, ROC.
Appl Microbiol Biotechnol. 2011 Aug;91(3):461-9. doi: 10.1007/s00253-011-3413-1. Epub 2011 Jun 18.
Alzheimer's disease is seen mainly in individuals over the age of 65, and the morbidity rate increases with age. Regarding the health function of Monascus-fermented red mold rice (RMR), besides hypolipidemic and hypotensive effects, other health functions of RMR such as anti-oxidation, cancer prevention, anti-fatigue, and anti-obesity have also been reported. Many published studies have shown the efficacy of RMR in the prevention of Alzheimer's disease. The current article discusses and provides evidence to support the beneficial potential of RMR in the prevention of Alzheimer's disease by discussing the pathogenic factors of Alzheimer's disease and the secondary metabolites of Monascus.
阿尔茨海默病主要见于 65 岁以上人群，发病率随年龄增长而增加。关于红曲米（Monascus-fermented red mold rice，RMR）的保健功能，除了具有降血脂、降血压的作用外，RMR 还具有抗氧化、防癌、抗疲劳、抗肥胖等其他保健功能也有报道。许多已发表的研究表明 RMR 对预防阿尔茨海默病有效。本文通过讨论阿尔茨海默病的发病机制和红曲霉菌的次级代谢产物，讨论了 RMR 预防阿尔茨海默病的有益潜力，并提供了相关证据。
