Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617, Taiwan.
Appl Microbiol Biotechnol. 2012 Mar;93(5):1831-42. doi: 10.1007/s00253-012-3891-9.
Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.
烟草和酒精的使用被报道为口腔癌发展的主要因素。红曲真菌已被用作东亚地区的传统中药几个世纪。红曲发酵产品含有许多功能性次级代谢产物，包括洛伐他汀、桔霉素、安卡黄素和红曲素。在我们实验室最近进行的几项研究中，这些次级代谢产物表现出抗炎、抗氧化和抗肿瘤活性。许多已发表的研究表明，红曲发酵产品在预防多种类型的癌症方面具有功效。本文讨论并提供证据支持，红曲发酵代谢产物可开发为口腔涂抹药物，以预防或治疗口腔癌发生。这是一种新型的治疗方法，侧重于肿瘤生长抑制，以提高患者的生存率和生活质量。
