颈清扫术治疗鼻咽癌局部区域失败与孤立性淋巴结失败的疗效。
Efficacy of neck dissection for locoregional failures versus isolated nodal failures in nasopharyngeal carcinoma.
机构信息
Department of Surgery, Division of Otorhinolaryngology-Head and Neck Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.
出版信息
Head Neck. 2012 May;34(5):638-42. doi: 10.1002/hed.21781. Epub 2011 Jun 17.
BACKGROUND
Neck dissection has been shown to be effective in controlling nodal failures in nasopharyngeal carcinoma. Its efficacy in controlling the disease in patients with synchronous locoregional failure is, however, not documented.
METHOD
A retrospective review of all patients who underwent neck dissection for nodal failures with or without treated local failure within 6 months was conducted for this study. The survivals of these 2 groups of patients were analyzed.
RESULTS
The 5-year overall survival of the whole cohort was 58%. There was no difference in 5-year disease specific survival (68% vs 40%; p = .121) and 5-year progression free survival (44% vs 36%; p = .334) when comparing patients with isolated nodal failures and synchronous locoregional failures. Multivariate analysis showed that only the initial N classification affects survival.
CONCLUSION
Neck dissection is efficacious in patients with nasopharyngeal carcinoma with nodal failure, with or without synchronous local failures.
背景
颈清扫术已被证明可有效控制鼻咽癌的淋巴结转移失败。然而，其在控制同期局部区域复发患者疾病方面的疗效尚未得到证实。
方法
本研究对所有因淋巴结转移失败而行颈清扫术的患者进行了回顾性分析，这些患者中有的同时存在局部区域复发，有的不存在。分析了这两组患者的生存情况。
结果
全队列患者的 5 年总生存率为 58%。比较孤立性淋巴结转移失败和同期局部区域复发的患者，5 年疾病特异性生存率（68% vs 40%；p =.121）和 5 年无进展生存率（44% vs 36%；p =.334）差异无统计学意义。多因素分析显示，只有初始 N 分类影响生存。
结论
颈清扫术对伴有或不伴有同期局部区域复发的鼻咽癌淋巴结转移失败患者有效。
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