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经手术清创、局部聚乙烯醇碘和抗生素治疗,坏死性诺卡氏菌性巩膜炎得以治愈。

Necrotizing nocardial scleritis successfully treated with surgical debridement and topical polyvinyl alcohol iodine and antibiotics.

机构信息

Shirai Hospital, Kagawa, Japan.

出版信息

J Ocul Pharmacol Ther. 2011 Aug;27(4):415-8. doi: 10.1089/jop.2011.0043. Epub 2011 Jun 20.

Abstract

PURPOSE

To report a case of necrotizing nocardial scleritis treated with surgical debridement and topical polyvinyl alcohol iodine (PAI) and antibiotics.

CASE

A 78-year-old man underwent phacoemulsification with intraocular lens implantation in the left eye. He had an uncomplicated postoperative course for 2 months but then developed infectious scleritis. The patient received intensive antibiotics treatments; however, the lesion did not respond. Because of the poor response, Nocardia infection was suspected, and the lesion was repeatedly scraped and the patient was treated with systemic trimethoprim/sulfamethoxazole (TMP-SMX, 800 mg/day) and topical PAI (0.033%, 4 times/day). Cultures of the scrapings grew Nocardia. The treatment led to a complete resolution of the infection.

CONCLUSIONS

Necrotizing nocardial scleritis can be treated by surgical debridement and systemic TMP-SMX and topical PAI.

摘要

目的

报告一例经手术清创及局部聚乙烯醇碘(PVA 碘)和抗生素治疗的坏死性奴卡氏菌性巩膜炎病例。

病例

一名 78 岁男性左眼行白内障超声乳化吸除联合人工晶状体植入术。术后 2 个月,患者恢复顺利,但随后出现感染性巩膜炎。患者接受了强化抗生素治疗,但病变未得到缓解。由于治疗反应不佳,怀疑为奴卡菌感染,病变部位反复刮除,并给予患者全身甲氧苄啶/磺胺甲噁唑(TMP-SMX,800mg/天)和局部 PVA 碘(0.033%,4 次/天)治疗。刮取物培养出奴卡菌。治疗后感染完全消退。

结论

坏死性奴卡氏菌性巩膜炎可通过手术清创、全身应用 TMP-SMX 和局部应用 PVA 碘治疗。

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