有梗阻和无梗阻的多囊性发育不良肾的免疫组织化学对比研究
Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction.
作者信息
Rojas Claudia P, Urbiztondo Arnel K, Bruce Jocelyn H, Rodriguez Maria M
机构信息
Department of Pathology, University of Miami, Holtz's Children's Hospital, Miami, Florida 33136, USA.
出版信息
Fetal Pediatr Pathol. 2011;30(4):209-19. doi: 10.3109/15513815.2011.572960. Epub 2011 Jun 20.
Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β-catenin in obstructive versus nonobstructive dysplasia.
多囊性发育不良肾（MCDK）的病因尚不清楚。并非所有病例都与梗阻有关。我们通过免疫组织化学方法，将17例MCDK（10例有梗阻，7例无梗阻）与17例对照及20例胎儿肾脏进行了比较。转化生长因子-β（TGF-β）在梗阻性MCDK中呈阴性，在非梗阻性MCDK中呈阳性。胰岛素样生长因子2（IGF2）在梗阻性MCDK中过度表达，在非梗阻性MCDK中表达不足。配对盒基因2（PAX2）、B细胞淋巴瘤-2（BCL-2）和β-连环蛋白在梗阻性和非梗阻性发育不良中表达相同。TGF-β和IGF2在梗阻性和非梗阻性MCDK中通过不同机制起作用，但在梗阻性与非梗阻性发育不良中，PAX2、BCL-2和β-连环蛋白之间没有差异。
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