输血依赖型骨髓增生异常综合征患者的心脏铁过载。
Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.
机构信息
Molecular Haematology Unit, Weatherall Institute of Molecular Medicine Department of Cardiology, Oxford, UK.
出版信息
Br J Haematol. 2011 Aug;154(4):521-4. doi: 10.1111/j.1365-2141.2011.08749.x. Epub 2011 Jun 21.
Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r=0·72, P<0·0001) and ferritin (r=0·53, P<0·0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53·7x10(5) Megaunits vs. 12·2x10(5) Megaunits, P=0·002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients.
依赖输血的骨髓增生异常综合征（MDS）患者容易发生铁过载。我们对 43 例接受 T2磁共振成像扫描的输血 MDS 患者进行了评估。81%的患者存在肝脏铁过载，16.8%的患者存在心脏铁过载。肝脏 R2（1000/T2*）与输血单位数（r=0.72，P<0.0001）和铁蛋白（r=0.53，P<0.0001）呈正相关，但心脏 R2*无此相关性。我们发现，在存在心脏铁负荷的患者中，时间-铁蛋白图的曲线下面积明显更大（中位数 53.7x10(5) Megaunits 比 12.2x10(5) Megaunits，P=0.002）。在这些患者中，HFE、HFE2、HAMP 或 SLC40A1 基因型并不是铁过载的预测因素。
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