Christchurch Hospital, Christchurch, New Zealand.
Colorectal Dis. 2011 Sep;13(9):e266-9. doi: 10.1111/j.1463-1318.2011.02673.x.
The study aimed to assess whether the ex vivo injection of patent blue V dye would increase lymph node yield in operative specimens of colorectal cancer.
A randomized controlled trial was carried out in which patients undergoing resection for colonic cancer were allocated to patent V blue or no patent blue V dye submucosal injection of the operative specimen. The number of lymph nodes found in each group was compared.
Between 1 January and 31 December 2008, 68 patients were randomized. Thirty-three patients received patent blue V dye and 34 did not. In the former group the median number of blue nodes identified was 11, compared with a median of 9 in the no dye group. After the application of Carnoy's solution lymph node count was 16 in each group. There was no significant difference between all these results.
Ex vivo injection of patent blue V dye submucosally in a peritumour location did not increase the lymph node count or the percentage of specimens having more than 12 lymph nodes identified.
本研究旨在评估在结直肠癌手术标本中应用专利蓝 V 染料是否会增加淋巴结检出数。
本研究采用随机对照试验，将接受结肠癌切除术的患者分为专利蓝 V 组和非专利蓝 V 染料黏膜下注射组。比较两组患者的淋巴结检出数。
2008 年 1 月 1 日至 12 月 31 日期间，共纳入 68 例患者。33 例患者接受了专利蓝 V 染料，34 例患者未接受。前者组中蓝染淋巴结的中位数为 11 枚，而无染料组的中位数为 9 枚。应用 Carnoy 溶液后，两组的淋巴结检出数均为 16 枚。这些结果之间无显著差异。
在肿瘤周围黏膜下应用专利蓝 V 染料进行离体注射并不能增加淋巴结检出数或增加检出 12 枚以上淋巴结的标本比例。
