爱泼斯坦-巴尔病毒与多发性硬化症

Epstein-Barr Virus and MS.

作者信息

Giovannoni G

机构信息

Gavin Giovannoni Neuroscience and Trauma Centre, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK, Tel: +44 20 7377 7472, Fax: +44 20 7377 7300, E-mail:

出版信息

Int MS J. 2011 May;17(2):44-9.

PMID:21689495

Abstract

Epstein-Barr virus (EBV) infection, particularly symptomatic infection, is closely associated with multiple sclerosis (MS). The strength of this association, the interaction of EBV infection with genetic risk factors and emerging immunological data have resulted in some investigators arguing that this association may be causative. Causation, however, is a complex science and more extensive and definitive data is required to convince the wider community that EBV is the pivotal factor in the complex causal pathway that ultimately leads to the development of MS.

摘要

爱泼斯坦-巴尔病毒（EBV）感染，尤其是有症状的感染，与多发性硬化症（MS）密切相关。这种关联的强度、EBV感染与遗传风险因素的相互作用以及新出现的免疫学数据，使得一些研究人员认为这种关联可能具有因果关系。然而，因果关系是一门复杂的科学，需要更广泛和确凿的数据来说服更广泛的群体，即EBV是最终导致MS发生的复杂因果途径中的关键因素。