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儿童溺水事件后与健康相关的生活质量。

Health-related quality of life after a drowning incident as a child.

机构信息

Department of Anaesthesia and Intensive Care, Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland.

出版信息

Resuscitation. 2011 Oct;82(10):1318-22. doi: 10.1016/j.resuscitation.2011.05.018. Epub 2011 Jun 1.

Abstract

AIM OF THE STUDY

To describe health-related quality of life (HRQoL), quality-adjusted life years (QALYs) gained and school performance in subjects having received either bystander or emergency medical service personnel initiated cardiopulmonary resuscitation (CPR) after a drowning incident in childhood.

MATERIALS AND METHODS

64 children admitted to pediatric intensive care (PICU) after successful CPR between 1985 and 2007. Eleven died in the PICU, 9 other within 6 months. In 2009 all long-term survivors, except for two, lived at home. Of the 40 patients eligible for the study, 29 (73%) responded to a questionnaire. HRQoL was assessed with the generic 15D, or its versions for adolescents (16D) or children (17D), and compared to that of general population. These HRQoL scores, age-specific survival probabilities, and HRQoL scores of the general population were used in a Markov model to estimate the number of QALYs gained.

RESULTS

Median age of the respondents was 17.3 (range: 3.0-28.4) years and 62% were male. At the time of drowning their median age had been 3.0 (range: 1.2-15.7) years. The drowning incident was associated with a significant loss in HRQoL in the oldest age group (total HRQoL total score 0.881 compared to 0.971 in the general population, P<0.01) but not in children (HRQoL score 0.944 vs. 0.938). When submersion time exceeded 10min mean HRQoL score was significantly lower than in patients with a shorter submersion (0.844 vs. 0.938, P=0.032). The mean undiscounted and discounted (at 3%) number of QALYs gained by treatment were 40.8 and 17.0, respectively.

CONCLUSIONS

A good HRQoL will be achieved in the majority of patients surviving long-term after a drowning incident in childhood, although HRQoL is affected by the submersion time.

摘要

研究目的

描述在儿童溺水事件后,由旁观者或急救医疗服务人员启动心肺复苏(CPR)的患者的健康相关生活质量(HRQoL)、质量调整生命年(QALYs)获益和学业表现。

材料和方法

1985 年至 2007 年间,64 名在儿科重症监护病房(PICU)接受成功 CPR 后入院的儿童。11 名在 PICU 死亡,9 名在 6 个月内死亡。2009 年,除 2 名患者外,所有长期幸存者均在家中生活。在符合研究条件的 40 名患者中,有 29 名(73%)回答了调查问卷。使用通用 15D 或其青少年版本(16D)或儿童版本(17D)评估 HRQoL,并与一般人群进行比较。这些 HRQoL 评分、特定年龄的生存概率以及一般人群的 HRQoL 评分被用于马尔可夫模型来估计 QALYs 的获益数量。

结果

受访者的中位年龄为 17.3 岁(范围:3.0-28.4 岁),62%为男性。溺水时的中位年龄为 3.0 岁(范围:1.2-15.7 岁)。溺水事件与最年长组的 HRQoL 显著丧失相关(总 HRQoL 总分 0.881,而一般人群为 0.971,P<0.01),但在儿童中没有(HRQoL 评分 0.944 与 0.938)。当浸泡时间超过 10 分钟时,平均 HRQoL 评分明显低于浸泡时间较短的患者(0.844 与 0.938,P=0.032)。未贴现和贴现(贴现率为 3%)的 QALYs 获益平均值分别为 40.8 和 17.0。

结论

在儿童溺水事件后长期存活的大多数患者中,将获得良好的 HRQoL,尽管 HRQoL 受到浸泡时间的影响。

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