Mayo School of Graduate Medical Education, Internal Medicine, Mayo Clinic, Siebens 5, 200 First Street SW, Rochester, MN 55905, USA.
Sleep Med. 2011 Aug;12(7):700-3. doi: 10.1016/j.sleep.2011.01.017.
Obstructive sleep apnea (OSA) has been associated with cardiac abnormalities. Whether any cardiac dysfunction is present in ischemic stroke patients with OSA is not known. The purpose of this study was to compare echocardiographic findings in ischemic stroke patients with and without OSA.
Nocturnal polysomnography was performed on 28 ischemic stroke subjects within 7 days of symptom onset. OSA was defined as an apnea-hypopnea index of ≥10. Echocardiographic variables were compared between the OSA and non OSA groups using Wilcoxon signed-rank, chi-square, or Fisher's exact tests.
The 14 (50%) subjects with OSA had comparable cardiac function and structure to those without OSA (n=14). Left ventricular (LV) mass index, LV ejection fraction, LV diastolic function, left atrial area, and right ventricular systolic function were not different between groups. Ischemic stroke subjects, regardless of their OSA status, had LV diastolic dysfunction with preserved systolic function.
Subjects with and without OSA, based on polysomnography in the first 7 days after stroke, have comparable right and left ventricular function.
阻塞性睡眠呼吸暂停（OSA）与心脏异常有关。患有 OSA 的缺血性脑卒中患者是否存在任何心功能障碍尚不清楚。本研究的目的是比较伴有和不伴有 OSA 的缺血性脑卒中患者的超声心动图检查结果。
在症状发作后 7 天内对 28 例缺血性脑卒中患者进行夜间多导睡眠图检查。OSA 定义为呼吸暂停低通气指数≥10。使用 Wilcoxon 符号秩检验、卡方检验或 Fisher 确切概率法比较 OSA 组和非 OSA 组的超声心动图变量。
14 例（50%）有 OSA 的患者与无 OSA 的患者（n=14）的心脏功能和结构相当。左心室质量指数、左心室射血分数、左心室舒张功能、左心房面积和右心室收缩功能在两组之间无差异。无论是否存在 OSA，缺血性脑卒中患者均存在左心室舒张功能障碍而收缩功能正常。
根据卒中后 7 天内的多导睡眠图检查，伴有和不伴有 OSA 的患者的左右心室功能相当。
