State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Mol Plant. 2011 Jul;4(4):601-6. doi: 10.1093/mp/ssr046. Epub 2011 Jun 20.
Gibberellic acid (GA) regulates many aspects of plant growth and development. The DELLA proteins act to restrain plant growth, and GA relieves this repression by promoting their degradation via the 26S proteasome pathway. The elucidation of the crystalline structure of the GA soluble receptor GID1 protein represents an important breakthrough for understanding the way in which GA is perceived and how it induces the destabilization of the DELLA proteins. Recent advances have revealed that the DELLA proteins are involved in protein-protein interactions within various environmental and hormone signaling pathways. In this review, we highlight our current understanding of the 'relief of repression' model that aims to explain the role of GA and the function of the DELLA proteins, incorporating the many aspects of cross-talk shown to exist in the control of plant development and the response to stress.
赤霉素（GA）调节植物生长和发育的许多方面。DELLA 蛋白作用于抑制植物生长，GA 通过促进它们在 26S 蛋白酶体途径中的降解来解除这种抑制。GA 可溶性受体 GID1 蛋白的晶体结构阐明代表了理解 GA 被感知的方式以及它如何诱导 DELLA 蛋白失稳的重要突破。最近的进展表明，DELLA 蛋白参与各种环境和激素信号通路中的蛋白质-蛋白质相互作用。在这篇综述中，我们强调了我们对“解除抑制”模型的理解，该模型旨在解释 GA 的作用和 DELLA 蛋白的功能，包括在控制植物发育和应对胁迫方面存在的许多交叉对话方面。
