Department of Health Management and Policy, School of Public Health, University of Michigan, 1113 Olivia Avenue, Ann Arbor, MI 48104, USA.
BMJ Qual Saf. 2011 Nov;20(11):914-22. doi: 10.1136/bmjqs.2010.047233. Epub 2011 Jun 20.
This study analyses patterns in reporting rates of medication errors, rates of medication errors with harm, and responses to the Safety Attitudes Questionnaire (SAQ), all in the context of four cultural and three system-level interventions for medication safety in an intensive care unit.
Over a period of 2.5 years (May 2007 to November 2009), seven overlapping interventions to improve medication safety and reporting were implemented: a poster tracking 'days since last medication error resulting in harm', a continuous slideshow showing performance metrics in the staff lounge, multiple didactic curricula, unit-wide emails summarising medication errors, computerised physician order entry, introduction of unit-based pharmacy technicians for medication delivery, and patient safety report form streamlining. The reporting rate of medication errors and errors with harm were analysed over time using statistical process control. SAQ responses were collected annually.
Subsequent to the interventions, the reporting rate of medication errors increased 25%, from an average of 3.16 to 3.95 per 10,000 doses dispensed (p<0.09), while the rate of medication errors resulting in harm decreased 71%, from an average of 0.56 to 0.16 per 10,000 doses dispensed (p<0.01). The SAQ showed improvement in all 13 survey items related to medication safety, five of which were significant (p<0.05).
Actively developing a transparent and positive safety culture at the unit level can improve medication safety. System-level mechanisms to promote medication safety are likely important factors that enable safety culture to translate into better outcomes, but may be independently ineffective in the face of poor safety culture.
本研究分析了在重症监护病房中,针对药物安全实施的四种文化和三种系统层面干预措施的背景下,药物错误报告率、有伤害的药物错误报告率以及对安全态度问卷(SAQ)的反应的模式。
在 2.5 年的时间内(2007 年 5 月至 2009 年 11 月),实施了七项重叠的药物安全和报告改进干预措施:一张海报跟踪“上次导致伤害的药物错误发生后至今的天数”,一个在休息室播放的连续幻灯片,显示绩效指标,多次教学课程,在整个单位范围内发送的电子邮件总结药物错误,计算机化医师医嘱录入,引入单位药剂师进行药物配送,以及简化患者安全报告表格。使用统计过程控制分析药物错误和有伤害的药物错误报告率随时间的变化。每年收集一次 SAQ 应答。
干预措施实施后,药物错误报告率增加了 25%,从平均每 10000 剂 3.16 次增加到 3.95 次(p<0.09),而导致伤害的药物错误率降低了 71%,从平均每 10000 剂 0.56 次降低到 0.16 次(p<0.01)。SAQ 在与药物安全相关的 13 个调查项目中均显示出改善,其中 5 项具有统计学意义(p<0.05)。
在单位层面积极发展透明和积极的安全文化可以提高药物安全性。促进药物安全的系统层面机制可能是将安全文化转化为更好结果的重要因素,但在面对不良安全文化时可能独立无效。