State Key Laboratory of Fine Chemicals, Dalian University of Technology, Linggong Road 2, 116024 Dalian, China.
Phys Chem Chem Phys. 2011 Jul 28;13(28):13026-33. doi: 10.1039/c1cp21038f. Epub 2011 Jun 21.
By comparison and combination of two strategies, extending π-conjugation and tuning Intramolecular Charge Transfer (ICT) effect, new long-wavelength BODIPY dyes have been efficiently synthesized. The new chromophores exhibit good optical properties: high fluorescence quantum yields, exceptionally large molar extinction coefficients, narrow red-emission bands, and relatively large Stokes shifts etc., in polar or apolar solvents. Besides, the new dyes, under transversal pumping at 532 nm, exhibit highly efficient and stable laser emission tunable from the green to NIR spectral region (570-725 nm). Moreover, one of these new BODIPY derivatives shows cell membrane permeability and bright intracellular red fluorescence. These advantageous characteristics assure the potential of these dyes for biophotonic applications.
通过两种策略的比较和结合，扩展了π-共轭并调整了分子内电荷转移（ICT）效应，高效地合成了新的长波 BODIPY 染料。这些新的生色团表现出良好的光学性质：在极性或非极性溶剂中具有高荧光量子产率、异常大的摩尔消光系数、窄的红光发射带和相对较大的斯托克斯位移等。此外，在 532nm 的横向泵浦下，这些新染料表现出高效且稳定的激光发射，可调谐范围从绿光到近红外光谱区（570-725nm）。此外，这些 BODIPY 衍生物中的一种具有细胞膜通透性和明亮的细胞内红色荧光。这些有利的特性保证了这些染料在生物光子学应用中的潜力。
