Miyamoto K, Sanae F, Kohei K, Nomura M, Koshiura R
Third Division of the Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University, Kanazawa.
Jpn J Cancer Res. 1990 Jun-Jul;81(6-7):557-9. doi: 10.1111/j.1349-7006.1990.tb02607.x.
Changes in numbers of alpha 1- and alpha 2-adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), were examined. alpha 1-Adrenergic receptors, measured in terms of [3H]prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. alpha 2-Adrenergic receptors, measured in terms of [3H]clonidine binding, transiently increased 3-fold over the control at 2 weeks. These changes in the early period of the 3'-MeDAB diet intake may be related to hepatocarcinogenesis.
研究了给雌性唐里大鼠喂食含0.06%致癌物质3'-甲基-4-二甲基氨基偶氮苯（3'-MeDAB）的饲料后，肝细胞质膜中α1-和α2-肾上腺素能受体数量的变化。以[3H]哌唑嗪结合来衡量的α1-肾上腺素能受体，在开始这种饮食2周后降至对照组的一半，然后在接下来的22周内逐渐下降。以[3H]可乐定结合来衡量的α2-肾上腺素能受体，在2周时短暂增加至对照组的3倍。在摄入3'-MeDAB饮食的早期阶段的这些变化可能与肝癌发生有关。
