Changes in number of alpha-adrenergic receptor subtypes in hepatocytes from rats fed 3'-methyl-4-dimethylaminoazobenzene.
作者信息
Miyamoto K, Sanae F, Kohei K, Nomura M, Koshiura R
机构信息
Third Division of the Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University, Kanazawa.
出版信息
Jpn J Cancer Res. 1990 Jun-Jul;81(6-7):557-9. doi: 10.1111/j.1349-7006.1990.tb02607.x.
Abstract
Changes in numbers of alpha 1- and alpha 2-adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), were examined. alpha 1-Adrenergic receptors, measured in terms of [3H]prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. alpha 2-Adrenergic receptors, measured in terms of [3H]clonidine binding, transiently increased 3-fold over the control at 2 weeks. These changes in the early period of the 3'-MeDAB diet intake may be related to hepatocarcinogenesis.
摘要
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