Alexander T S, Rosenthal K S
Department of Pathology, Akron City Hospital, OH.
J Lab Clin Med. 1990 Sep;116(3):400-7.
The protective capability of autologous anti-herpes simplex virus type 1 (anti-HSV-1) antibody was analyzed in immunosuppressed mice. Immunologically naive, immunosuppressed mice infected with a low-passage clinical HSV-1 isolate developed local site lesions, monoplegia, paraplegia, and died within 8 days. Mice that had recovered from a previous HSV-1 infection and were immunosuppressed with cyclophosphamide and then rechallenged with live virus showed no symptoms and survived. Untreated mice that had recovered from infection (primed mice) had high titers of anti-HSV-1 antibody and a delayed type hypersensitivity (DTH) response to virus challenge. Cyclophosphamide treatment, but not lethal irradiation, could ablate the DTH response, resulting in a lack of antivirus cell-mediated immunity. Antibody was the only demonstrable protective immune function in the cyclophosphamide-treated animals. This indicates that cell-mediated immunity is not required for protection against HSV-1 challenge in individuals with virus-specific antibody.
在免疫抑制小鼠中分析了自体抗1型单纯疱疹病毒（抗HSV-1）抗体的保护能力。免疫未致敏的免疫抑制小鼠感染低传代临床HSV-1分离株后出现局部病变、单瘫、截瘫，并在8天内死亡。曾感染过HSV-1且已康复的小鼠，用环磷酰胺进行免疫抑制，然后用活病毒再次攻击，未出现症状并存活下来。从感染中康复的未治疗小鼠（致敏小鼠）具有高滴度的抗HSV-1抗体，并且对病毒攻击有迟发型超敏反应（DTH）。环磷酰胺治疗而非致死性照射可消除DTH反应，导致缺乏抗病毒细胞介导的免疫。在环磷酰胺治疗的动物中，抗体是唯一可证明的保护性免疫功能。这表明，对于具有病毒特异性抗体的个体，抵御HSV-1攻击并不需要细胞介导的免疫。
