Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500607, India.
Org Biomol Chem. 2011 Sep 7;9(17):5978-88. doi: 10.1039/c1ob05411b. Epub 2011 Jun 22.
An efficient alumina-supported CuO-catalyzed O-arylation of phenols and aliphatic alcohols with various aryl as well as heteroaryl halides under ligand-free conditions are reported. This protocol provides a variety of diaryl ether and bis-diaryl ether motifs by reacting different aryl/aliphatic halides with differently substituted phenols and saturated alcohols in the presence of a catalytic amount of CuO on alumina and KOH as a base at moderate temperature under nitrogen atmosphere. The described methodology is simple, straightforward and efficient to afford the cross-coupled products in high yields under ligand-free conditions. The explored catalyst is inexpensive, air-stable and recyclable up to three cycles.
报道了一种在无配体条件下，氧化铝负载的氧化铜高效催化酚类和脂肪醇与各种芳基以及杂芳基卤化物的 O-芳基化反应。该反应在氮气氛围下，温和温度下，以 CuO/氧化铝为催化剂，KOH 为碱，通过不同取代酚类和饱和醇与不同芳基/脂肪基卤化物反应，提供了多种二芳基醚和双二芳基醚结构。该方法简单、直接、高效，在无配体条件下以高产率得到交叉偶联产物。所研究的催化剂价格低廉、空气稳定，可循环使用三到三次。
