Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalm, Israel.
Chem Soc Rev. 2011 Nov;40(11):5282-92. doi: 10.1039/c1cs15086c. Epub 2011 Jun 22.
Transition metal ions can be both beneficial and harmful to biological systems if not carefully regulated. A family of proteins that include a conserved sequence in their binding site of MXCXXC is responsible for delivery and homeostasis of different metals. Model studies present an effective tool for studying the parameters governing metal affinity, selectivity and other mechanistic aspects. Small-molecule, peptide-based, and advanced models will be presented, as well as functional models of potential industrial applications.
过渡金属离子如果得不到妥善控制，可能对生物系统既有好处也有坏处。一类蛋白质在其结合位点含有保守序列 MXCXXC，负责不同金属的输送和体内平衡。模型研究为研究控制金属亲和力、选择性和其他机械方面的参数提供了有效工具。将介绍小分子、基于肽的和先进模型，以及具有潜在工业应用的功能模型。
