Tammakorn Chutima, Mongkolsuk Tasanee, Thammanichanond Duangtawan, Pakakasama Samart, Kitpoka Pimpun
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2011 Jun;94(6):738-42.
Killer cell Immunoglobulin-like Receptors (KIRs) are members of a group of molecules expressed on the surfaces of natural killer (NK) cells and some T cells. KIRs recognize MHC class I molecules on target cells. The interaction of these molecules regulates NK cell reactivity. The KIR gene cluster is highly polymorphic in individuals and different populations.
Determine the frequencies and diversities of KIR genes among the Thai population.
Seventeen KIR genes and common subtypes were identified in 500 healthy Thai blood donors by PCR-SSP. The framework genes KIR2DL4, KIR3DL2, KIR3DL3, and KIR3DP1 were present in all individuals (100%). The observed frequencies of KIR genes vary in the presented population. The most frequent non-framework KIR gene was KIR2DLI (98.4%) while the least frequent was KIR2DL5B (24.2%).
It was observed that the Thai population shows polymorphism of the KIR genes and the diversities of KIR genes in Thai differed from other populations. These data might be of benefit to future studies of the KIR gene and its association with diseases.
杀伤细胞免疫球蛋白样受体（KIRs）是在自然杀伤（NK）细胞和一些T细胞表面表达的一组分子的成员。KIRs识别靶细胞上的MHC I类分子。这些分子的相互作用调节NK细胞的反应性。KIR基因簇在个体和不同人群中具有高度多态性。
确定泰国人群中KIR基因的频率和多样性。
通过聚合酶链反应-序列特异性引物（PCR-SSP）在500名健康泰国献血者中鉴定出17种KIR基因和常见亚型。框架基因KIR2DL4、KIR3DL2、KIR3DL3和KIR3DP1在所有个体中均存在（100%）。在所呈现的人群中，观察到的KIR基因频率有所不同。最常见的非框架KIR基因是KIR2DLI（98.4%），而最不常见的是KIR2DL5B（24.2%）。
观察到泰国人群显示出KIR基因的多态性，且泰国人群中KIR基因的多样性与其他人群不同。这些数据可能有助于未来对KIR基因及其与疾病关联的研究。
