Kolhatkar Rohit, Lote Asawari, Khambati Hiren
Department of Biopharmaceutical Sciences, University of Illinois Chicago, Rockford, USA.
Curr Drug Discov Technol. 2011 Sep;8(3):197-206. doi: 10.2174/157016311796799044.
Folic acid, transferrin and integrin alpha v beta 3 (αvβ3) receptors are overexpressed in various cancer cell lines. Ligands having high affinity for these receptors are often conjugated to nanocarriers to facilitate the tumor localization of therapeutic agents. In this review the use of these ligands for targeted delivery using liposomes, dendrimers and (N-(2-hydroxypropyl) methacrylamide) (HPMA) copolymers is discussed. Emphasis is placed on discussing drug delivery systems that have been optimized for in-vitro binding as well as in-vivo pharmacokinetics. Our aim is to understand the various factors influencing the targeting ability of nanocarriers.
叶酸、转铁蛋白和整合素αvβ3受体在多种癌细胞系中过表达。对这些受体具有高亲和力的配体通常与纳米载体偶联，以促进治疗剂在肿瘤部位的定位。在这篇综述中，讨论了这些配体在使用脂质体、树枝状大分子和（N-（2-羟丙基）甲基丙烯酰胺）（HPMA）共聚物进行靶向递送方面的应用。重点讨论了针对体外结合以及体内药代动力学进行优化的药物递送系统。我们的目的是了解影响纳米载体靶向能力的各种因素。
