Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Diabetes Res Clin Pract. 2011 Oct;94(1):14-21. doi: 10.1016/j.diabres.2011.05.033. Epub 2011 Jun 21.
Cardiovascular complications are a chief cause of mortality and morbidity in diabetic patients. Recent studies suggest that epigenetic changes which may arise as a consequence of environmental factors play an important role in predisposition to disease. Epigenetic mechanisms such as DNA methylation, chromatin remodeling and histone modifications regulate the gene expression in response to environmental signals. Role of epigenetics has been recognized in the pathology of diabetes, however its role in diabetic associated cardiomyopathy remains largely unexplored. In this article, we review current literature on the epigenetic mechanisms involved in diabetes and discuss recent evidence of epigenetic changes that may play an important role in pathophysiology of DCM.
心血管并发症是糖尿病患者死亡和发病的主要原因。最近的研究表明，可能由环境因素引起的表观遗传变化在疾病易感性中起着重要作用。表观遗传机制，如 DNA 甲基化、染色质重塑和组蛋白修饰，可调节基因表达以响应环境信号。在糖尿病的病理学中已经认识到了表观遗传学的作用，但其在糖尿病相关心肌病中的作用在很大程度上仍未得到探索。本文综述了涉及糖尿病的表观遗传机制的现有文献，并讨论了可能在 DCM 病理生理学中起重要作用的表观遗传变化的最新证据。
