Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan.
J Microbiol Immunol Infect. 2011 Dec;44(6):430-4. doi: 10.1016/j.jmii.2011.04.013. Epub 2011 Jun 22.
Group B Streptococcus (GBS) (Streptococcus agalactiae) is an important pathogen in neonates, pregnant women, and adults with underlying disease.
Fifty clinical isolates were collected during the period 2001-2004 and analyzed by multilocus sequence typing and capsular serotyping.
The six major sequence types (STs) identified by multilocus sequence typing were ST1, ST12, ST19, ST17, ST23, and ST10. Five major clonal complexes (CCs) and one single ST (ST61) from 11 different STs were found. CC1 (n=14) was the most common one, followed by CC12 (n=13), CC19 (n=9), CC17 (n=7), and CC23 (n=6). The most common serotypes were serotype III, followed by Ib, V, Ia, and IV. The most invasive strains in adults belonged to ST1 (CC1) and serotype V, and those in neonates belonged to ST17 (CC17) and serotype III. In addition, ST19 was distributed in adults and neonates.
These results are similar to those of previous reports, but some geographic differences were found, suggesting that limited clonal lineages play important roles in GBS-associated diseases worldwide. Continued tracking of GBS in the population through clinical isolates is important for epidemiologic investigations and vaccine development.
B 群链球菌（GBS）（无乳链球菌）是新生儿、孕妇和患有基础疾病的成年人中的重要病原体。
在 2001-2004 年期间收集了 50 株临床分离株，并通过多位点序列分型和荚膜血清型分析进行分析。
通过多位点序列分型鉴定的 6 种主要序列型（ST）分别为 ST1、ST12、ST19、ST17、ST23 和 ST10。从 11 种不同 ST 中发现了 5 个主要克隆复合体（CC）和 1 个单一 ST（ST61）。CC1（n=14）是最常见的，其次是 CC12（n=13）、CC19（n=9）、CC17（n=7）和 CC23（n=6）。最常见的血清型是 III 型，其次是 Ib、V、Ia 和 IV。成人中最具侵袭性的菌株属于 ST1（CC1）和 V 型，新生儿中则属于 ST17（CC17）和 III 型。此外，ST19 分布于成人和新生儿中。
这些结果与之前的报告相似，但也发现了一些地理差异，表明有限的克隆谱系在全球范围内与 GBS 相关疾病中发挥重要作用。通过临床分离株持续跟踪人群中的 GBS 对于流行病学调查和疫苗开发非常重要。
