Dolot Rafał, Ozga Magdalena, Krakowiak Agnieszka, Nawrot Barbara
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences, Łódź, Poland.
Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):601-7. doi: 10.1107/S0907444911015605. Epub 2011 Jun 14.
Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine-triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the first complete structure of the rabbit HINT1-adenosine complex is reported at 1.10 Å resolution, which is one of the highest resolutions obtained for a HINT1 structure. The final structure has an R(cryst) of 14.25% (R(free) = 16.77%) and the model exhibits good stereochemical qualities. A detailed analysis of the atomic resolution data allowed an update of the details of the protein structure in comparison to previously published data.
组氨酸三联体核苷酸结合蛋白1（HINT1）代表了组氨酸三联体蛋白超家族中最古老且分布最广泛的分支。HINT1在多种生物学过程中发挥重要作用，并且已在许多物种中被发现。在此，报道了兔HINT1-腺苷复合物的首个完整结构，分辨率为1.10 Å，这是HINT1结构所获得的最高分辨率之一。最终结构的R(cryst)为14.25%（R(free)=16.77%），且模型具有良好的立体化学性质。与先前发表的数据相比，对原子分辨率数据的详细分析使得蛋白质结构的细节得以更新。
