Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.
Am J Perinatol. 2011 Oct;28(9):689-94. doi: 10.1055/s-0031-1280597. Epub 2011 Jun 22.
We describe the epidemiological characteristics and identify maternal-fetal outcomes in pregnancies complicated by gastroschisis. We retrospectively reviewed 115 cases of gastroschisis at the University of Mississippi Medical Center. The incidence of gastroschisis trended upward between 2000 and 2008. Significant proportions of mothers were nonobese, nulliparous, teenagers, smokers, and nonconsumers of alcohol. Infants delivered at > 36 weeks or without sepsis had shorter hospital stay (HS) and interval to full enteral feeding (FEF). The rates of low birth weight (LBW), fetal growth restriction, and spontaneous preterm birth (PTB) were 63%, 45%, and 24%, respectively. Bowel atresia was noted in 9%. Rates of primary closure (25%), neonatal sepsis (29%), fetal death (2%), and infant mortality (4%) were notable. Median HS and interval to FEF were 40 and 30 days, respectively. The incidence of gastroschisis is increasing in Mississippi. Sepsis, LBW, and PTB are key determinants of poor infant outcomes.
我们描述了患有先天性脐膨出的妊娠的流行病学特征，并确定了母婴结局。我们回顾性地分析了密西西比大学医学中心的 115 例先天性脐膨出病例。先天性脐膨出的发病率在 2000 年至 2008 年呈上升趋势。很大一部分母亲是非肥胖、未生育、青少年、吸烟者，并且不饮酒。在 >36 周分娩或无败血症的婴儿的住院时间（HS）和完全肠内喂养（FEF）间隔较短。低出生体重（LBW）、胎儿生长受限和自发性早产（PTB）的发生率分别为 63%、45%和 24%。9%的婴儿出现肠闭锁。原发性闭合（25%）、新生儿败血症（29%）、胎儿死亡（2%）和婴儿死亡（4%）的发生率也很高。HS 和 FEF 的中位数分别为 40 天和 30 天。密西西比州先天性脐膨出的发病率正在上升。败血症、LBW 和 PTB 是婴儿不良结局的关键决定因素。
