[Na-pump regulation by liponucleotides:its mechanism and physiological significance].

A short-term regulation of Na,K-ATPase by the long-chain fatty acid esters and coenzyme A (liponucleotides) has been studied. It has been found that in the presence of liponucleotides the maximum velocity of ATP-hydrolysis doesn't change, but the apparent KM value decreases. While studying the ion transport it has been shown that palmitoyl-CoA stimulates the pump approaching the cell membrane from the cytoplasmic side, being an intracellular regulator of Na,K-ATPase. A possible mechanism of liponucleotide action on the process of enzyme functioning and its physiological implications is discussed.