Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Enzyme Inhib Med Chem. 2012 Apr;27(2):223-31. doi: 10.3109/14756366.2011.585135. Epub 2011 Jun 24.
A new series of six chromone-derived compounds and their Cu(II) complexes have been synthesized and characterized by their physical, spectral and analytical data. The ligands and their Cu(II) complexes were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains by agar-well diffusion method. The ligands were found to exhibit either no or low-to-moderate activities against one or more bacterial species whereas, the Cu(II) complexes exhibited moderate-to-high activity. The ligands which were inactive before complexation became active upon complexation with the Cu(II) metal ion and less active became more active.
已合成并通过物理、光谱和分析数据对一系列六种色酮衍生化合物及其 Cu(II) 配合物进行了表征。通过琼脂孔扩散法筛选了配体及其 Cu(II) 配合物对四种革兰氏阴性（大肠杆菌、铜绿假单胞菌、伤寒沙门氏菌、福氏志贺菌）和两种革兰氏阳性（枯草芽孢杆菌、金黄色葡萄球菌）细菌菌株的体外抗菌活性。配体对一种或多种细菌的活性要么没有，要么低至中等。而 Cu(II) 配合物则表现出中等至高等的活性。在与 Cu(II) 金属离子配位之前没有活性的配体在配位后变得具有活性，而活性较低的配体变得更具有活性。
