使用尿选择性α1-受体阻滞剂治疗可改善排尿和性功能：泰国下尿路症状男性的研究。

Treatment with a uroselective α1-blocker improves voiding and sexual function: a study in Thai men with lower urinary tract symptoms.

机构信息

Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

J Sex Med. 2011 Sep;8(9):2582-9. doi: 10.1111/j.1743-6109.2011.02359.x. Epub 2011 Jun 23.

DOI:10.1111/j.1743-6109.2011.02359.x

PMID:21699664

Abstract

INTRODUCTION

Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) negatively affect quality of life. The α1-blockers are effective for LUTS suggestive of benign prostatic hypertrophy.

AIM

To analyze the effect of a uroselective α1-blocker on both voiding and sexual dysfunction in Thai men with LUTS.

METHODS

Of 488 men with LUTS who received 10 mg alfuzosin monotherapy once daily (OD) at a men's health clinic, 313 men (64%) completed 8 months of alfuzosin treatment and filled the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function (IIEF)-5 questionnaires.

MAIN OUTCOME MEASURE

The relationships among the IPSS, IIEF-5 score, and select clinical characteristics were analyzed using multiple regression analysis. To identify changes from the baseline, the chi-square or Fisher's exact test was used for categorical or dichotomous variables and a paired Student's t-test was used for continuous variables.

RESULTS

The 313 men were followed up for a mean (standard deviation [SD]) of 35.6 (2.2) weeks. LUTS were categorized by IPSS as moderate in 100 patients (31.9%) and severe in 213 patients (68.1%). ED was graded according to the IIEF-5 as normal in 46 patients (14.7%), mild in 29 patients (9.3%), mild to moderate in 81 patients (25.9%), moderate in 47 patients (15.0%), and severe in 110 patients (35.1%). ED is associated with LUTS (P=0.008). After 8 months of alfuzosin treatment, the mean (SD) IPSS and IIEF-5 score significantly improved from 19.95 (6.4) to 11.13 (4.6) (P<0.001) and from 11.5 (6.9) to 14.9 (5.7) (P<0.001), respectively. However, the IIEF-5 score did not improve significantly in patients with severe LUTS as determined using the IPSS. The most common adverse event with alfuzosin treatment was mild (dizziness, 2.2%).

CONCLUSION

Treatment with 10 mg alfuzosin OD is safe and effective in improving voiding and sexual function in Thai men with LUTS and ED.

摘要

简介

下尿路症状（LUTS）和勃起功能障碍（ED）会降低生活质量。α1-受体阻滞剂对良性前列腺增生引起的 LUTS 有效。

目的

分析选择性α1-受体阻滞剂对泰国男性 LUTS 患者排尿和性功能的影响。

方法

在男性健康诊所，488 名 LUTS 男性接受每日一次 10mg 阿夫唑嗪单药治疗（OD），其中 313 名（64%）男性完成了 8 个月的阿夫唑嗪治疗，并填写了国际前列腺症状评分（IPSS）和国际勃起功能指数（IIEF-5）问卷。

主要观察指标

采用多元回归分析分析 IPSS、IIEF-5 评分与选择临床特征之间的关系。使用卡方检验或 Fisher 精确检验分析分类或二分类变量，使用配对学生 t 检验分析连续变量，以确定从基线的变化。

结果

313 名男性的平均（标准差[SD]）随访时间为 35.6（2.2）周。LUTS 根据 IPSS 分为中度 100 例（31.9%）和重度 213 例（68.1%）。ED 根据 IIEF-5 分级为正常 46 例（14.7%）、轻度 29 例（9.3%）、轻度至中度 81 例（25.9%）、中度 47 例（15.0%）和重度 110 例（35.1%）。ED 与 LUTS 相关（P=0.008）。阿夫唑嗪治疗 8 个月后，IPSS 和 IIEF-5 评分的平均（SD）分别从 19.95（6.4）显著改善至 11.13（4.6）（P<0.001）和 11.5（6.9）至 14.9（5.7）（P<0.001）。然而，在使用 IPSS 确定严重 LUTS 的患者中，IIEF-5 评分的改善并不显著。阿夫唑嗪治疗最常见的不良反应是轻度（头晕，2.2%）。