Hayani A, Venger B H, Rouah E, Laurent J P, Mahoney D H, McClain K L
Department of Hematology/Oncology, Texas Children's Hospital, Baylor College of Medicine, Houston 77030.
Cancer. 1990 Oct 15;66(8):1856-60. doi: 10.1002/1097-0142(19901015)66:8<1856::aid-cncr2820660835>3.0.co;2-n.
A case of primary leptomeningeal B-cell lymphoma in an 8-year-old, previously healthy child is described. The child was found to have hypogammaglobulinemia, and the Epstein-Barr virus genome was identified in cultured tumor cells despite blood serology being negative for the virus. The patient was treated with cyclophosphamide, doxorubicin, vincristine, and dexamethasone, plus intrathecal methotrexate, and initially improved. Before the initiation of craniospinal radiation, the patient developed progressive disease, deteriorated, and died 9 months after the onset of symptoms.
本文描述了一例8岁、此前健康的儿童原发性柔脑膜B细胞淋巴瘤病例。该患儿被发现存在低丙种球蛋白血症，尽管血液血清学检测该病毒为阴性，但在培养的肿瘤细胞中鉴定出了爱泼斯坦-巴尔病毒基因组。患者接受了环磷酰胺、阿霉素、长春新碱和地塞米松治疗，外加鞘内注射甲氨蝶呤，最初病情有所改善。在开始全脑全脊髓放疗之前，患者病情进展，症状恶化，并在症状出现9个月后死亡。
