Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Epilepsy Res. 2011 Sep;96(1-2):172-5. doi: 10.1016/j.eplepsyres.2011.05.012. Epub 2011 Jun 22.
The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.
生酮饮食（KD）是婴儿痉挛症（IS）的一种治疗方法。在这里，我们研究 KD 在治疗医学难治性 IS 中的疗效，检查其对婴儿生长的影响，并探讨其作用机制。在 KD 开始后的 1-3 个月，26 名患者中有 46%的患者 IS 减少了 90%以上。未发现 IS 减少与血清 β-羟基丁酸或葡萄糖水平之间存在显著关系。此外，KD 并未显著改变患者的生长参数。因此，与先前的研究一致，我们证明 KD 是一种耐受良好且有效的 IS 治疗方法。
