Paediatric Research Centre, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland.
Eur Respir J. 2012 Jan;39(1):76-80. doi: 10.1183/09031936.00040211. Epub 2011 Jun 23.
Asthma risk is lower after wheezing associated with respiratory syncytial virus (RSV) than with non-RSV infection in infancy. RSV is the main wheezing-associated virus in infants aged <6 months. We evaluated the outcome of children hospitalised for bronchiolitis at <6 months of age, with special focus on viral aetiology and early risk factors. Out of 205 infants hospitalised for bronchiolitis at <6 months of age, 127 (62%) attended a control visit at a mean age of 6.5 yrs and the parents of an additional 39 children were interviewed by telephone. Thus, follow-up data collected by identical structured questionnaires were available from 166 (81%) children. Viral aetiology of bronchiolitis, studied on admission by antigen detection or PCR, was demonstrable in 97% of cases. Current asthma was present in 21 (12.7%) children: 8.2% in the 110 former RSV patients versus 24% in non-RSV patients (p=0.01). 45 (27%) children had ever had asthma. In adjusted analyses, atopic dermatitis, non-RSV bronchiolitis and maternal asthma were independently significant early-life risk factors for asthma. The risk of asthma was lower after RSV bronchiolitis than after bronchiolitis caused by other viruses in children hospitalised at <6 months of age.
与非 RSV 感染相比，呼吸道合胞病毒（RSV）相关喘息后哮喘风险较低。RSV 是 <6 月龄婴儿喘息相关的主要病毒。我们评估了 <6 月龄因细支气管炎住院的儿童的结局，特别关注病毒病因学和早期危险因素。在因细支气管炎住院的 205 名 <6 月龄婴儿中，127 名（62%）在平均年龄为 6.5 岁时接受了随访，另外 39 名儿童的父母通过电话接受了访谈。因此，166 名（81%）儿童可获得通过相同的结构化问卷收集的随访数据。通过抗原检测或 PCR 在入院时研究细支气管炎的病毒病因学，97%的病例可检测到病毒。目前有 21 名（12.7%）儿童患有哮喘：110 名前 RSV 患儿中有 8.2%，而非 RSV 患儿中有 24%（p=0.01）。45 名（27%）儿童曾有哮喘。在调整分析中，特应性皮炎、非 RSV 细支气管炎和母亲哮喘是婴儿 <6 月龄住院后哮喘的独立早期危险因素。与其他病毒引起的细支气管炎相比，<6 月龄因 RSV 细支气管炎住院的儿童哮喘风险较低。
