Atrium Medical Centre, The Netherlands.
Cephalalgia. 2011 Jul;31(10):1145-9. doi: 10.1177/0333102411412087. Epub 2011 Jun 23.
Rapid recurrence of a new cluster headache attack following oxygen treatment was named the 'rebound effect' by Kudrow (1981). It has never been studied properly. To study this effect, we defined it as a more rapid than usual (for the individual patient) recurrent cluster headache attack after complete relief following oxygen therapy, or an increase in the number of attacks per 24 hours while using oxygen therapy as acute attack treatment. We reviewed the literature and searched our cluster headache study databases.
In our eight patients with rebound cluster headache, the effect was experienced following 87.5% of oxygen treated attacks. Duration until the next cluster headache attack was on average 894 minutes shorter and frequency was on average 1.6 cluster headache attacks per day higher than without oxygen therapy.
Although the 1981 trial reported a prevalence of 25%, rebound cluster headache following oxygen therapy is rarely reported nowadays. This may be due to better techniques in oxygen application, the use of higher oxygen flow rates or underreporting. The few literature data and data on our eight patients did not provide clues about the mechanism of the rebound effect. Further study, applying the proposed definition, seems useful.
库德罗（1981 年）将氧气治疗后新发集群性头痛发作迅速复发的现象命名为“反弹效应”。该现象从未得到过恰当的研究。为了研究该效应，我们将其定义为在接受氧气治疗完全缓解后，比个体患者通常情况下更快地复发集群性头痛发作，或者在使用氧气治疗急性发作时，每 24 小时发作次数增加。我们回顾了文献并搜索了我们的集群性头痛研究数据库。
在我们的 8 例出现反弹性集群性头痛的患者中，该效应出现在 87.5%接受氧气治疗的发作之后。与不接受氧气治疗相比，下一次集群性头痛发作的平均间隔时间缩短了 894 分钟，平均每日集群性头痛发作频率增加了 1.6 次。
尽管 1981 年的试验报告反弹性集群性头痛的患病率为 25%，但如今这种现象很少有报道。这可能是由于氧气应用技术的改进、更高的氧气流速的使用或报告不足所致。少量的文献数据和我们 8 例患者的数据并未提供有关反弹效应机制的线索。进一步的研究，应用所提出的定义，似乎是有用的。
