ω-3 脂肪酸对大型胃癌手术后的血清乳酸水平没有影响。

ω-3 Fatty acids have no impact on serum lactate levels after major gastric cancer surgery.

机构信息

Department of General Surgery, Ege University, School of Medicine, Bornova-Izmir, Turkey.

出版信息

JPEN J Parenter Enteral Nutr. 2011 Jul;35(4):488-92. doi: 10.1177/0148607110386611.

DOI:10.1177/0148607110386611

PMID:21700966

Abstract

BACKGROUND

Preoperative and intraoperative nutrition support in patients undergoing major surgery results in decreased incidence of morbidity and mortality. Studies investigating the role of ω-3 fatty acids in these patients are increasing. Some are focused on perfusion at the cellular level. This study was undertaken to address the effect of postoperative administration of ω-3 fatty acids on cellular hypoperfusion associated with major gastric surgery.

METHODS

Twenty-six patients undergoing gastric cancer surgery were randomly assigned to receive parenteral nutrition (PN) supplemented with a combination of ω-6 and ω-3 fatty acids (Omegaven, 0.2 g/kg/d; Lipovenoes 10%, 0.6 g/kg/d) or with ω-6 fatty acid (Lipovenoes 10%, 0.8 g/kg/d) for 5 days. Blood samples were taken preoperatively, postoperative day 1, and on the last day of PN therapy (day 5).

RESULTS

Patients receiving ω-3 and ω-6 fatty acids showed neither lower serum lactate levels nor lower rates of complications compared with patients receiving ω-6 only. There were no statistically significant differences between the groups in other biochemical parameters, complications, or length of hospital stay or mortality.

CONCLUSION

PN with ω-3 fatty acid supplementation does not have a significant impact on cellular hypoperfusion and lactate clearance after major gastric surgery.

摘要

背景

在接受大手术的患者中进行术前和术中营养支持可降低发病率和死亡率。研究ω-3 脂肪酸在这些患者中的作用的研究越来越多。一些研究集中在细胞水平的灌注上。本研究旨在探讨术后给予ω-3 脂肪酸对与大胃手术相关的细胞低灌注的影响。

方法

26 例行胃癌手术的患者被随机分配接受肠外营养（PN）补充ω-6 和 ω-3 脂肪酸（ω-3 脂肪酸，0.2 g/kg/d；Lipovenoes 10%，0.6 g/kg/d）或仅 ω-6 脂肪酸（Lipovenoes 10%，0.8 g/kg/d）5 天。在术前、术后第 1 天和 PN 治疗的最后一天（第 5 天）采集血样。