Department of Ophthalmology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Ophthalmic Res. 2012;47(1):47-51. doi: 10.1159/000328631. Epub 2011 Jun 23.
Glaucoma is the second leading cause of blindness worldwide. To date, several publications have evaluated the association between the tumor necrosis factor α (TNF-α) -308G/A polymorphism and glaucoma risk. However, the results remain inconclusive. The aim of our study was to clarify the effect of the TNF-α -308G/A polymorphism on glaucoma risk.
We conducted searches of the published literature in the PubMed database updated to May 2010. A meta-analysis was performed by critically reviewing 7 publications with a total of 1,199 glaucoma cases and 1,189 controls on the -308G/A polymorphism. Odds ratio (OR) and 95% confidence intervals (CIs) were used to assess the strength of this relationship.
Overall, no association between the TNF-α -308G/A polymorphism and primary open-angle glaucoma or pseudoexfoliation glaucoma risk was found in the A allele versus G allele genetic model (OR = 1.68, 95% CI = 0.78-3.59 or OR = 2.44, 95% CI = 0.40-15.04, respectively), the same as genetic models in AG versus GG and AA + AG versus GG. In the stratified analysis by ethnicity and source of control subgroups, a significant association was still not observed in all genetic models.
Our meta-analysis provides strong evidence that the TNF-α -308G/A polymorphism is not associated with different forms of glaucoma risk.
青光眼是全球第二大致盲原因。迄今为止，已有多项出版物评估了肿瘤坏死因子-α（TNF-α）-308G/A 多态性与青光眼风险之间的关系。然而，结果仍不确定。本研究旨在阐明 TNF-α-308G/A 多态性对青光眼风险的影响。
我们在截至 2010 年 5 月的 PubMed 数据库中进行了文献检索。通过对 7 项出版物进行严格的综述，对总共 1199 例青光眼病例和 1189 例对照的-308G/A 多态性进行了荟萃分析。使用比值比（OR）和 95%置信区间（CI）来评估这种关系的强度。
总体而言，在 A 等位基因与 G 等位基因的遗传模型中，TNF-α-308G/A 多态性与原发性开角型青光眼或假性剥脱性青光眼风险之间没有关联（OR=1.68，95%CI=0.78-3.59 或 OR=2.44，95%CI=0.40-15.04），在 AG 与 GG 和 AA+AG 与 GG 的遗传模型中也是如此。在按种族和对照组来源进行的分层分析中，在所有遗传模型中均未观察到显著相关性。
我们的荟萃分析提供了强有力的证据表明，TNF-α-308G/A 多态性与不同类型的青光眼风险无关。
