Miyoshi Takushi, Takebayashi Shinji, Suzuki Chiaki, Hiwatashi Nao, Ikeda Hiroki, Ono Kazuo, Miura Makoto
Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan.
ORL J Otorhinolaryngol Relat Spec. 2011;73(4):201-5. doi: 10.1159/000328977. Epub 2011 Jun 23.
Radiation-induced sarcoma usually develops after an interval of more than 10 years from the completion of radiation therapy to the diagnosis of secondary sarcoma. However, the theory of radiation-induced transformation does not rule out postirradiation sarcomas with a short latency period. We experienced the case of a patient with postirradiation leiomyosarcoma of the tongue, which occurred 19 months after he had received chemoradiotherapy. Besides the short latency period, a pseudotumor stage developed between the time of radiation exposure and the development of leiomyosarcoma. In this article, we also describe an immunohistochemical approach to diagnose leiomyosarcoma and the efficacy of a gemcitabine and docetaxel regimen.
放射性肉瘤通常在放射治疗结束至继发性肉瘤诊断之间间隔超过10年后发生。然而，辐射诱导转化理论并不排除潜伏期短的放疗后肉瘤。我们遇到一例舌部放疗后平滑肌肉瘤患者，该患者在接受放化疗19个月后发病。除了潜伏期短外，在辐射暴露至平滑肌肉瘤发生之间还出现了假瘤期。在本文中，我们还描述了诊断平滑肌肉瘤的免疫组化方法以及吉西他滨和多西他赛方案的疗效。
