L-天冬氨酸：鲤鱼视网膜中视锥光感受器突触传递作用的证据。
L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
作者信息
Wu S M, Dowling J E
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5205-9. doi: 10.1073/pnas.75.10.5205.
Abstract
A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.
摘要
在对鲤鱼视网膜的L型视锥水平细胞进行细胞内记录时，应用了多种假定的神经递质物质及其拮抗剂。在所有测试的物质中，发现L-天冬氨酸是在暗适应、部分光适应和经CO₂处理的视网膜中使这些水平细胞去极化的最有效物质。此外，L-天冬氨酸拮抗剂DL-α-氨基己二酸可阻断内源性光感受器递质和外源性应用的L-天冬氨酸对水平细胞的作用。结果表明，L-天冬氨酸和天然递质与水平细胞膜上同一群突触后受体相互作用。
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