TAKO-centre, Lovisenberg Diakonale Hospital, Oslo, Norway.
Int J Paediatr Dent. 2012 Jan;22(1):27-36. doi: 10.1111/j.1365-263X.2011.01153.x. Epub 2011 Jun 27.
BACKGROUND. Prader-Willi syndrome (PWS) is a rare complex multisystemic genetic disorder. AIM. The objective of this study was to provide a systematic assessment of whole saliva secretion and oral manifestations associated with PWS. DESIGN. Fifty individuals (5-40 years) with PWS and an age- and sex-matched control group were included. Whole saliva was collected. All participants underwent an anamnestic interview. Radiological and dental clinical examinations were carried out to identify hypodontia, dental caries, enamel defects and gingival inflammation. RESULTS. Mean whole salivary flow rate was 0.12 ± 0.11 mL/min in the study group compared with 0.32 ± 0.20 mL/min in the control group (P < 0.001). Hypodontia was significantly more common in PWS (P < 0.001), and dental caries in the age group >19 years was significantly lower in PWS (P = 0.04) compared with the controls. There was no significant difference in the prevalence of dental caries in the primary dentition or in the frequency of enamel defects in the permanent dentition between the two groups. Median Gingival Index was significantly higher in the Prader-Willi group compared with the controls (P = 0.02). CONCLUSIONS. Low salivary flow is a consistent finding in PWS. Nevertheless, despite dry mouth and dietary challenges, dental caries is not increased in Norwegian individuals with PWS.
普拉德-威利综合征（PWS）是一种罕见的复杂多系统遗传性疾病。目的：本研究旨在系统评估与 PWS 相关的全唾液分泌和口腔表现。设计：纳入 50 名（5-40 岁）PWS 患者和年龄、性别匹配的对照组。收集全唾液。所有参与者均接受病史访谈。进行影像学和牙科临床检查以确定缺牙、龋齿、牙釉质缺陷和牙龈炎症。结果：研究组全唾液流速的平均值为 0.12 ± 0.11 mL/min，而对照组为 0.32 ± 0.20 mL/min（P < 0.001）。PWS 中缺牙明显更常见（P < 0.001），与对照组相比，PWS 中>19 岁年龄组的龋齿明显更低（P = 0.04）。两组间乳牙龋齿的患病率或恒牙釉质缺陷的频率无显著差异。与对照组相比，Prader-Willi 组的牙龈指数中位数显著更高（P = 0.02）。结论：低唾液流是 PWS 的一致发现。然而，尽管有口干和饮食挑战，挪威 PWS 患者的龋齿并没有增加。
