Machado Fernanda Campos, de Souza Ivete Pomarico Ribeiro, Portela Maristela Barbosa, de Araújo Soares Rosangela Maria, Freitas-Fernandes Liana Bastos, Castro Gloria Fernanda
Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pediatr Dent. 2011 Mar-Apr;33(2):153-7.
The purpose of this study was to evaluate chlorhexidine to control gingivitis and Candida species (spp.) in children infected with the human immunodeficiency virus (HIV) and their acceptance of the therapy.
Twenty-six HIV+ children were selected, and oral exam-established biofilm, gingival indexes, and stimulated saliva were collected for Candida ssp. identification. The children brushed their teeth for 21 days with chlorhexidine gel (0.2%). Salivary samples, biofilm, and gingival indexes were collected after 21-days and again 35 days after ceasing gel use. The children answered a questionnaire about the therapy.
All children tested positive for Candida and gingivitis. After 21 days, Candida counts and gingivitis decreased in 25 and 26 children, respectively. Mean reduction was approximately 68% for Candida spp. and 74% for gingivitis. Thirty-five days after discontinuing gel use, gingivitis and Candida spp. increased in 13 and 16 patients, respectively. Considering the Candida spp., the heavy growth was lower in the first re-evaluation. Candida albicans was the most frequent species. Approximately 85% did not experience inconvenience with the gel, and approximately 48% thought it was good for tooth-brushing.
Chlorhexidine therapy may be an option to treat and pre- vent gingivitis and reduce yeast counts in children infected with HIV.
本研究旨在评估洗必泰对感染人类免疫缺陷病毒（HIV）儿童的牙龈炎及念珠菌属感染的控制效果，以及他们对该治疗方法的接受程度。
选取26名HIV阳性儿童，收集其通过口腔检查确定的生物膜、牙龈指数，并采集刺激性唾液用于念珠菌属鉴定。这些儿童使用0.2%的洗必泰凝胶刷牙21天。在使用凝胶21天后以及停止使用凝胶35天后，再次收集唾液样本、生物膜和牙龈指数。儿童回答了一份关于该治疗方法的问卷。
所有儿童念珠菌检测及牙龈炎检测均呈阳性。21天后，25名儿童的念珠菌计数下降，26名儿童的牙龈炎有所减轻。念珠菌属平均减少约68%，牙龈炎平均减轻74%。停止使用凝胶35天后，分别有13名和16名患者的牙龈炎和念珠菌属感染有所增加。就念珠菌属而言，首次重新评估时重度生长情况有所减轻。白色念珠菌是最常见的菌种。约85%的儿童未感到该凝胶带来不便，约48%的儿童认为其有助于刷牙。
洗必泰治疗可能是治疗和预防感染HIV儿童的牙龈炎及减少酵母菌数量的一种选择。
