Department of Urology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Urology. 2011 Aug;78(2):301-8. doi: 10.1016/j.urology.2011.04.030. Epub 2011 Jun 23.
Coexisting conditions associated with interstitial cystitis/painful bladder syndrome (IC/PBS) have not been fully explored by IC/PBS subtypes. We compared comorbid diagnoses/symptoms in women with ulcerative (ULC) and nonulcerative (N-ULC) IC/PBS and controls.
Adult women with IC/PBS and controls without IC/PBS completed a mailed survey assessing for 21 diagnoses. IC/PBS subtype was determined by hydrodistention reports. Standardized questionnaires assessed IC/PBS symptoms (Interstitial Cystitis Symptom/Problem Indexes [ICSI-PI]) and for undiagnosed fibromyalgia, irritable bowel syndrome, and depression (Symptom Intensity Score [SIS]; Rome III Functional Bowel Questionnaire; Center for Epidemiologic Studies Depression Scale [CES-D]). Data were analyzed using the Pearson chi-square, Fisher exact, Wilcoxon rank test, or Spearman rank correlation coefficient.
Of 178 N-ULC IC/PBS patients, 36 ULC IC/PBS patients, and 425 controls, ULC IC/PBS subjects were older (median 63 years; P < .01) and less employed (P < .01), but groups were similar on other demographic characteristics. N-ULC reported more chronic diagnoses (mean 3.5 ± 2.3) than ULC (2.3 ± 2.0) and controls (1.2 ± 1.5) (P < .01). When N-ULC and ULC IC/PBS patients were compared, more N-ULC IC/PBS patients had fibromyalgia (P = .03), migraines (P = .03), temporomandibular joint disorder (P < .01), and higher CES-D (P = .02) and SIS scores (P = .01). The ULC IC/PBS group voided more frequently during the daytime (P = .03) and nighttime (P < .01) and had smaller mean bladder capacity than N-ULC (P < .01). No significant differences were seen between N-ULC and ULC IC/PBS patients on the ICSI-PI and Rome III.
Notable differences in the number of comorbid diagnoses and symptoms were seen between IC/PBS subtypes and controls. Subtypes should continue to be evaluated individually to ascertain other similarities and differences.
共存病症与间质性膀胱炎/膀胱疼痛综合征（IC/PBS）有关，但尚未通过 IC/PBS 亚型进行充分研究。我们比较了溃疡性（ULC）和非溃疡性（N-ULC）IC/PBS 患者与对照组的合并诊断/症状。
患有 IC/PBS 和无 IC/PBS 的成年女性完成了一项邮寄调查，评估了 21 种诊断。通过注水扩张报告确定 IC/PBS 亚型。标准化问卷评估了 IC/PBS 症状（间质性膀胱炎症状/问题指数 [ICSI-PI]）和未诊断的纤维肌痛、肠易激综合征和抑郁（症状强度评分 [SIS]；罗马 III 功能性肠病问卷；流行病学研究中心抑郁量表 [CES-D]）。使用 Pearson 卡方检验、Fisher 确切检验、Wilcoxon 秩检验或 Spearman 秩相关系数分析数据。
在 178 名 N-ULC IC/PBS 患者、36 名 ULC IC/PBS 患者和 425 名对照组中，ULC IC/PBS 患者年龄较大（中位数 63 岁；P <.01）且就业人数较少（P <.01），但其他人口统计学特征相似。N-ULC 报告的慢性诊断（平均 3.5 ± 2.3）多于 ULC（2.3 ± 2.0）和对照组（1.2 ± 1.5）（P <.01）。当比较 N-ULC 和 ULC IC/PBS 患者时，更多的 N-ULC IC/PBS 患者患有纤维肌痛（P =.03）、偏头痛（P =.03）、颞下颌关节紊乱（P <.01）、CES-D 评分（P =.02）和 SIS 评分（P =.01）较高。ULC IC/PBS 组白天（P =.03）和夜间（P <.01）排尿次数更多，平均膀胱容量小于 N-ULC（P <.01）。在 ICSI-PI 和罗马 III 方面，N-ULC 和 ULC IC/PBS 患者之间未见显著差异。
IC/PBS 亚型与对照组之间存在明显的合并诊断和症状数量差异。应继续单独评估亚型，以确定其他相似点和差异。
