Nutrition Unit, Hospital Ramón y Cajal, and CIBERobn, Instituto Carlos III, Madrid, Spain.
Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):836-42. doi: 10.1016/j.numecd.2011.01.007. Epub 2011 Jun 23.
The aim of this study is to validate a semi-quantitative Food Frequency Questionnaire (FFQ) used for general population in Spain, in patients with familial hypercholesterolaemia (FH).
Subjects with genetic diagnosis of FH were randomly selected from the Spanish FH Registry. They completed an FFQ based in 113 food items at inclusion (FFQ1) and after 1 year (FFQ2), and a 3-day dietary records (DR) every 3 months. Detailed instruction about how to register foods and beverages was given by a trained nutritionist. Each DR and FFQ was systematically coded, and the daily nutrients intake in absolute, percentage and nutrient density terms were estimated using a software system based on food composition tables. Pearson correlation coefficient was calculated with correction-repeated measurements to assess the reproducibility of both FFQ and the four 3-day DRs, as well as the validity of FFQ comparing to the mean of 3 days' DR.
A total of 112 subjects (58 females and 54 males, aged 43 ± 16 years) finished the study. There were no differences between FFQ1, FFQ2 and mean FFQ (FFQa) in mean absolute and percentage values of selected daily nutrients' intake. Comparison between FFQ1, FFQ2, FFQa and the mean of four 3-day DRs was statistically significant in all absolute values, but not in percentage or nutrient density terms. Corrected Pearson correlation coefficient ranged from 0.470 to 0.952 for mean values of all nutrients, except alcohol.
This study demonstrated that FFQ is a reliable tool to assess the dietary pattern in FH patients.
本研究旨在验证一种用于西班牙普通人群的半定量食物频率问卷（FFQ），用于家族性高胆固醇血症（FH）患者。
从西班牙 FH 登记处随机选择有遗传诊断 FH 的受试者。他们在纳入时（FFQ1）和 1 年后（FFQ2）完成了基于 113 种食物的 FFQ，并每 3 个月进行 3 天饮食记录（DR）。一名经过培训的营养师提供了有关如何记录食物和饮料的详细说明。每个 DR 和 FFQ 都进行了系统编码，并使用基于食物成分表的软件系统估计了绝对、百分比和营养素密度术语中的每日营养素摄入量。使用校正重复测量计算 Pearson 相关系数，以评估两种 FFQ 和四种 3 天 DR 的可重复性，以及 FFQ 与 3 天 DR 平均值相比的有效性。
共有 112 名受试者（58 名女性和 54 名男性，年龄 43 ± 16 岁）完成了研究。在选定的每日营养素摄入量的平均值和百分比值方面，FFQ1、FFQ2 和平均 FFQ（FFQa）之间没有差异。FFQ1、FFQ2、FFQa 与四个 3 天 DR 的平均值之间的比较在所有绝对值上均具有统计学意义，但在百分比或营养素密度方面则不然。校正后的 Pearson 相关系数范围为 0.470 至 0.952，适用于所有营养素的平均值，除了酒精。
本研究表明，FFQ 是评估 FH 患者饮食模式的可靠工具。
