Pre-clinical screening of immunomodulatory compounds using the parent-into-F1 model.
作者信息
Via Charles S
出版信息
Clin Immunol. 2011 Sep;140(3):212-5. doi: 10.1016/j.clim.2011.06.001. Epub 2011 Jun 12.
Abstract
摘要
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本文引用的文献
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Effects of oligodeoxynucleotide with CCT repeats on chronic graft versus host disease induced experimental lupus nephritis in mice.寡核苷酸 CCT 重复序列对慢性移植物抗宿主病诱导的实验性狼疮肾炎的影响。
Clin Immunol. 2011 Sep;140(3):300-6. doi: 10.1016/j.clim.2011.04.016. Epub 2011 May 4.
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Donor CD8 T cells and IFN-gamma are critical for sex-based differences in donor CD4 T cell engraftment and lupus-like phenotype in short-term chronic graft-versus-host disease mice.供体 CD8 T 细胞和 IFN-γ 对于短期慢性移植物抗宿主病小鼠中供体 CD4 T 细胞植入和狼疮样表型的性别差异至关重要。
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CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice.CD8+ T 调节细胞表达 Ly49 类 I MHC 受体，并且在自身免疫倾向的 B6-Yaa 小鼠中存在缺陷。
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2010-5. doi: 10.1073/pnas.1018974108. Epub 2011 Jan 13.
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Enhancement of suboptimal CD8 cytotoxic T cell effector function in vivo using antigen-specific CD80 defective T cells.利用抗原特异性 CD80 缺陷 T 细胞增强体内亚最佳 CD8 细胞毒性 T 细胞效应功能。
J Immunol. 2011 Jan 1;186(1):291-304. doi: 10.4049/jimmunol.0902370. Epub 2010 Nov 29.
5
Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance.滤泡辅助性 T 细胞（follicular helper T cells）受 CD8(+) 调节性 T 细胞（regulatory T cells）抑制对于自身耐受至关重要。
Nature. 2010 Sep 16;467(7313):328-32. doi: 10.1038/nature09370.
6
Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression.供者 CD8 T 细胞的激活对于雌性慢性移植物抗宿主病小鼠更严重的肾脏疾病至关重要，并且与脾脏中 ICOS(hi)宿主 CD4 T 细胞和 IL-21 表达的增加有关。
Clin Immunol. 2010 Jul;136(1):61-73. doi: 10.1016/j.clim.2010.01.005. Epub 2010 May 6.
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CD8+ Tregs in lupus, autoimmunity, and beyond.狼疮、自身免疫及其他疾病中的 CD8+ Tregs。
Autoimmun Rev. 2010 Jun;9(8):560-8. doi: 10.1016/j.autrev.2010.03.006. Epub 2010 Apr 10.
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Inflammatory cytokines as a third signal for T cell activation.炎症细胞因子作为 T 细胞活化的第三信号。
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Advances in lupus stemming from the parent-into-F1 model.狼疮研究的新进展源于亲代至 F1 代模型。
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A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways.具有 CCT 重复序列的人源微卫星 DNA 模拟寡脱氧核苷酸通过选择性 TLR 通路负调控 TLR7/9 介导的固有免疫反应。
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