Division of Immunohematology, Azienda Ospedaliero-Univeritaria Pisana, via Paradisa 2, Pisa, Italy.
Biol Blood Marrow Transplant. 2011 Nov;17(11):1585-8. doi: 10.1016/j.bbmt.2011.06.004. Epub 2011 Jun 16.
Donor-specific antihuman leukocyte antigen antibodies (DSHA) have been clearly implicated in graft rejection in solid organ transplantation. Their role in allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains unclear. We summarize here evidence supporting a role for DSHA in graft failure in animal models of allo-HSCT and in clinical settings whenever no full HLA matching occurs.
供体特异性抗人白细胞抗原抗体（DSHA）已明确与实体器官移植中的移植物排斥反应有关。其在异基因造血干细胞移植（allo-HSCT）中的作用尚不清楚。本文总结了支持 DSHA 在 allo-HSCT 动物模型和不完全 HLA 匹配的临床情况下导致移植物失功的证据。
