ENVIRON International Corporation, Amherst, MA 01002, United States.
Vaccine. 2011 Aug 11;29(35):6035-41. doi: 10.1016/j.vaccine.2011.06.028. Epub 2011 Jun 23.
To evaluate the potential for long-term or delayed onset health effects, we extended a previous cohort study of disability separation from the army associated with vaccination against anthrax. Analyses included stratified Cox proportional hazards and multiple logistic regression models. Forty-one percent of 1,001,546 soldiers received at least one anthrax vaccination; 5.21% were evaluated for disability. No consistent patterns or statistically significant differences in risk of disability evaluation, disability determination, or reason for disability were associated with anthrax vaccination. There was a dose-related trend in risk of disability for soldiers with 2 years' service, limited to those entering service in 2000 or later. Divergent patterns in risk suggest confounding by temporal or occupational risks of disability.
为了评估长期或延迟出现的健康影响的可能性，我们扩展了先前关于接种炭疽疫苗与军队残疾退役相关的队列研究。分析包括分层 Cox 比例风险和多逻辑回归模型。在 1001546 名士兵中，41%至少接种过一次炭疽疫苗；5.21%接受了残疾评估。炭疽疫苗接种与残疾评估、残疾判定或残疾原因的风险之间没有一致的模式或统计学上显著差异。对于服务年限为 2 年的士兵，残疾风险存在剂量相关趋势，仅限于 2000 年或之后入伍的士兵。风险的不同模式表明残疾的时间或职业风险存在混杂。
