Department of Otolaringology, Fundación Alcorcón University Hospital, Alcorcón, Madrid, Spain.
J Voice. 2012 Jul;26(4):496-501. doi: 10.1016/j.jvoice.2011.03.006. Epub 2011 Jun 25.
An acoustic analysis was conducted of the voice of 25 patients with Parkinson's disease (PD) subjected to deep brain stimulation (DBS) to assess the impact of therapy.
We examined 25 patients with advanced PD under four different conditions: deprived of medical treatment, under medical treatment, and one week and one month after the implant of the DBS electrodes. At the four time points, the patients produced a sustained /a/ and a standard sentence in Spanish, and microphone and electroglottographic recordings were digitally analyzed using the Computerized Speech Lab program.
Waveform analysis of the sustained /a/ captured by the microphone indicated a higher fundamental frequency (F(0)) when the patients were under levodopa treatment. The frequency perturbation (jitter) decreased remarkably after the three treatments. Shimmer also fell, but differences were not significant.
Nearly all acoustic analysis parameters during phonation of a sustained /a/ improved after DBS, but the factor that was most sensitive to the impact of both surgical and medical therapy was jitter.
对 25 例接受深部脑刺激 (DBS) 治疗的帕金森病 (PD) 患者的声音进行了声学分析，以评估治疗的影响。
我们检查了 25 例处于以下四种不同状态的晚期 PD 患者：未接受药物治疗、接受药物治疗、植入 DBS 电极一周后和一个月后。在这四个时间点，患者分别发出持续/a/和西班牙语标准句子，使用 Computerized Speech Lab 程序对麦克风和电声门图记录进行数字分析。
麦克风记录的持续/a/的声谱图分析表明，在左旋多巴治疗时，基频 (F(0)) 更高。三种治疗后，频率微扰 (抖动) 显著降低。颤音也下降，但差异不显著。
在持续/a/发音期间，几乎所有声学分析参数在 DBS 后都有所改善，但最敏感于手术和药物治疗影响的因素是抖动。
