Genovesi S, Protasoni G, Assi C, Golin R, Stella A, Zanchetti A
Istituto di Clinica Medica Generale e Terapia Medica, University of Milan, Italy.
J Hypertens. 1990 Aug;8(8):703-10. doi: 10.1097/00004872-199008000-00003.
We studied neural influences on the renal actions of atrial peptides in anaesthetized cats by comparing the response to atrial natriuretic factor (ANF) infusion in the innervated kidney and in the contralateral surgically denervated kidney. During ANF infusion arterial pressure decreased, the heart rate did not change and blood flow to both kidneys increased slightly. Vascular conductances became slightly but significantly higher in the denervated kidneys than in the controls. In both kidneys, the glomerular filtration rate increased transiently and significantly. Inhibition of renin release was more prompt and larger in the innervated than in the denervated kidneys. ANF infusion caused a significant increase in sodium and water excretion from both the innervated and denervated kidneys. However, the diuretic and natriuretic effect in the innervated kidneys, although proportionally greater than that in the denervated kidneys, was of shorter duration and subsided after 20 min of ANF infusion. Efferent renal nerve activity did not change during the initial 10 min of ANF infusion but thereafter increased progressively and significantly. We conclude that the effects of atrial peptides on renin release and excretory functions are influenced by renal nerve activity.
我们通过比较麻醉猫的支配肾和对侧手术去神经肾对心房利钠因子（ANF）输注的反应，研究了神经对心房肽肾脏作用的影响。在输注ANF期间，动脉压下降，心率不变，双侧肾脏的血流量略有增加。去神经肾的血管传导率比对照肾略有但显著升高。在双侧肾脏中，肾小球滤过率短暂且显著增加。肾素释放的抑制在支配肾比去神经肾更迅速且更明显。输注ANF导致支配肾和去神经肾的钠和水排泄显著增加。然而，支配肾的利尿和利钠作用虽然按比例大于去神经肾，但持续时间较短，在输注ANF 20分钟后消退。在输注ANF的最初10分钟内，肾传出神经活动没有变化，但此后逐渐且显著增加。我们得出结论，心房肽对肾素释放和排泄功能的影响受肾神经活动的影响。
