Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, USA.
Am J Epidemiol. 2011 Jul 15;174(2):211-8. doi: 10.1093/aje/kwr036. Epub 2011 Jun 24.
Recent work suggests that infertility treatment is associated with adverse child health outcomes. In exploring various methods of assembling a cohort of children conceived by infertility treatment, the authors conducted a validation study of the assisted reproductive technology and infertility drug use check boxes on the Massachusetts birth certificate. Using 2001 and 2002 data, the authors conducted telephone interviews with 399 women whose child's birth certificate had at least one of the boxes checked along with 185 women who were over age 42 years or who delivered twins or higher order multiples to compare the check box information with maternal report. Among the 579 women with available information, the birth certificate was fully concordant with respect to infertility treatment status for 271 (47%) women, partially concordant for 248 (43%) women, and discordant for 60 (10%) women. Agreement between the birth certificate and maternal report was good for singletons (weighted kappa = 0.66) but was found to be very poor among twins and higher order multiples (weighted kappa = 0.05). The authors concluded that birth certificates are an efficient means of locating children conceived with the help of infertility treatment but that they are not appropriate for identifying type of treatment.
最近的研究表明，不孕治疗与儿童健康不良结局有关。在探索通过各种方法组建一个由不孕治疗受孕的儿童队列时，作者对马萨诸塞州出生证明上的辅助生殖技术和不孕药物使用复选框进行了验证研究。利用 2001 年和 2002 年的数据，作者对 399 名其子女出生证明上至少有一个复选框被选中的妇女以及 185 名年龄在 42 岁以上或分娩双胞胎或更高多胞胎的妇女进行了电话访谈，将复选框信息与母亲报告进行了比较。在 579 名有可用信息的妇女中，出生证明在 271 名（47%）妇女的不孕治疗状况方面完全一致，在 248 名（43%）妇女方面部分一致，在 60 名（10%）妇女方面不一致。出生证明与母亲报告之间的一致性对于单胞胎（加权 κ = 0.66）很好，但在双胞胎和更高多胞胎中则非常差（加权 κ = 0.05）。作者得出结论，出生证明是一种有效的方法，可以找到在不孕治疗帮助下受孕的儿童，但它们不适合识别治疗类型。
