建立一个以夫妻生育和儿童发展为重点的基于人群的出生队列的方法学：上州儿童研究。
Methodology for establishing a population-based birth cohort focusing on couple fertility and children's development, the Upstate KIDS Study.
机构信息
Division of Intramural Population Health Research, Rockville, MD.
出版信息
Paediatr Perinat Epidemiol. 2014 May;28(3):191-202. doi: 10.1111/ppe.12121. Epub 2014 Mar 25.
BACKGROUND
Critical data gaps remain regarding infertility treatment and child development. We assessed the utility of a birth certificate registry for developing a population cohort aimed at answering such questions.
METHODS
We utilised the Upstate New York livebirth registry (n = 201,063) to select births conceived with (n = 4024) infertility treatment or exposed infants, who were then frequency-matched by residence to a random sample of infants conceived without (n = 14,455) treatment or unexposed infants, 2008-10. Mothers were recruited at 2-4 months postpartum and queried about their reproductive histories, including infertility treatment for comparison with birth certificate data. Overall, 1297 (32%) mothers of exposed and 3692 of unexposed (26%) infants enrolled.
RESULTS
Twins represented 22% of each infant group. The percentage of infants conceived with/without infertility treatment was similar whether derived from the birth registry or maternal report: 71% none, 16% drugs or intrauterine insemination, and 14% assisted reproductive technologies (ART). Concordant reporting between the two data sources was 93% for no treatment, 88% for ART, and 83% for fertility drugs, but differed by plurality. Exposed infants had slightly (P < 0.01) earlier gestations than unexposed infants (38.3 ± 2.8 and 38.7 ± 2.7 weeks, respectively) based upon birth certificates but not maternal report (38.7 ± 2.7 and 38.7 ± 2.9, respectively). Conversely, mean birthweight was comparable using birth certificates (3157 ± 704 and 3194 ± 679 g, respectively), but differed using maternal report (3167 ± 692 and 3224 ± 661, respectively P < 0.05).
CONCLUSIONS
The birth certificate registry is a suitable sampling framework as measured by concordance with maternally reported infertility treatment. Future efforts should address the impact of factors associated with discordant reporting on research findings.
背景
关于不孕治疗和儿童发育，仍存在关键数据空白。我们评估了出生证明登记处的实用性，以建立一个旨在回答此类问题的人群队列。
方法
我们利用纽约州北部的活产登记处（n=201063）选择了接受不孕治疗（n=4024）或暴露于不孕治疗的婴儿，然后根据居住地将这些婴儿与随机选择的未接受治疗（n=14455）或未暴露于不孕治疗的婴儿进行频率匹配，时间为 2008 年至 2010 年。母亲在产后 2-4 个月时被招募，并询问其生殖史，包括与出生证明数据进行比较的不孕治疗史。共有 1297 名暴露组（32%）和 3692 名未暴露组（26%）婴儿的母亲入组。
结果
双胞胎分别占每组婴儿的 22%。根据出生登记处或母亲报告得出的接受不孕治疗和未接受不孕治疗的婴儿比例相似：71%无治疗，16%药物或宫腔内人工授精，14%辅助生殖技术（ART）。两种数据源的一致性报告率分别为无治疗的 93%、ART 的 88%和生育药物的 83%，但存在多胎差异。根据出生证明，暴露组婴儿的胎龄略早于未暴露组（分别为 38.3±2.8 和 38.7±2.7 周）（P<0.01），但根据母亲报告则没有差异（分别为 38.7±2.7 和 38.7±2.9 周）。相反，根据出生证明，平均出生体重相似（分别为 3157±704 和 3194±679 克），但根据母亲报告则存在差异（分别为 3167±692 和 3224±661 克，P<0.05）。
结论
根据与母亲报告的不孕治疗的一致性，出生证明登记处是一个合适的抽样框架。未来的工作应解决与不一致报告相关的因素对研究结果的影响。
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