Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Pancreas. 2011 Oct;40(7):1029-33. doi: 10.1097/MPA.0b013e3182207893.
The current classification of pancreatic cancer is based only on anatomic location of metastatic lymph nodes (LNs). On the other hand, the number of metastatic LNs has been used in staging of colorectal, esophageal, and gastric cancers. The aim of this study was to assess the prognostic impact of the number or ratio of the metastatic LNs in pancreatic body and tail carcinoma.
Eighty-five patients with pancreatic body and tail adenocarcinoma who underwent pancreatectomy were included. Location, number, ratio of metastatic LNs, and the survival of patients were analyzed.
Forty patients with LN metastasis had poor prognosis (P = 0.007). The prognoses of patients with 5 or more metastatic LNs were poorer than those with less than 5 metastatic LNs (P = 0.046), and patients with a metastatic LN ratio of 0.2 or more had the worst prognosis. Multivariate analysis revealed that 5 or more metastatic LNs and metastatic LN ratio of 0.2 or more were independent prognostic factors for survival (P = 0.0015 and P = 0.014, respectively).
These results indicate that the number and the ratio of metastatic LNs can be used to predict poor patient survival and as a staging strategy.
目前胰腺癌的分类仅基于转移性淋巴结（LNs）的解剖位置。另一方面，转移性 LNs 的数量已被用于结直肠癌、食管癌和胃癌的分期。本研究旨在评估胰体尾腺癌中转移性 LNs 的数量或比率对预后的影响。
纳入 85 例接受胰体尾腺癌切除术的患者。分析患者的淋巴结转移位置、数量、比率以及生存情况。
40 例有淋巴结转移的患者预后较差（P = 0.007）。有 5 个或更多转移性 LNs 的患者预后比少于 5 个转移性 LNs 的患者差（P = 0.046），而转移性 LNs 比率为 0.2 或更高的患者预后最差。多变量分析显示，5 个或更多转移性 LNs 和转移性 LNs 比率为 0.2 或更高是生存的独立预后因素（P = 0.0015 和 P = 0.014）。
这些结果表明，转移性 LNs 的数量和比率可用于预测患者的不良预后，并作为一种分期策略。
