Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Pancreas. 2011 Nov;40(8):1289-94. doi: 10.1097/MPA.0b013e31821fcc3b.
DNA sequence variants in the cyclooxygenase-2 (COX-2) gene may lead to altered COX-2 production and/or activity, resulting in interindividual differences in susceptibility to pancreatic cancer. To test this hypothesis, we investigated the relationship between polymorphisms in the COX-2 gene and the risk of pancreatic cancer in a European population.
The COX-2 genotypes for 7 single-nucleotide polymorphisms (rs2745557, rs5277, rs2066826, rs4648261, rs4648262, rs2206593, and rs5275) were determined in 162 pancreatic cancer patients and 170 control subjects without cancer who were matched for age and sex. Data analysis was by conditional logistic regression analysis, adjusting for age, sex, and smoking.
Two haplotypes (GGAGGGT and GCGGGGT for rs2745557, rs5277, rs2066826, rs4648261, rs4648262, rs2206593, rs5275, respectively) were more frequent among the patients compared with control subjects (P < 0.024), although no individually statistically significant associations for the 7 single-nucleotide polymorphisms studied were detected.
Our findings suggest the individual polymorphisms we studied in the COX-2 gene are not associated with risk of pancreatic cancer. However, the finding of a modest association with 2 haplotypes might be consistent with a small effect, which could be also seen at the genotype level had more samples been available.
环氧化酶-2（COX-2）基因中的 DNA 序列变异可能导致 COX-2 产生和/或活性改变，从而导致个体对胰腺癌易感性的差异。为了检验这一假说，我们在欧洲人群中研究了 COX-2 基因多态性与胰腺癌风险之间的关系。
在 162 例胰腺癌患者和 170 例年龄和性别匹配的无癌症对照者中，确定了 COX-2 基因 7 个单核苷酸多态性（rs2745557、rs5277、rs2066826、rs4648261、rs4648262、rs2206593 和 rs5275）的基因型。数据分析采用条件逻辑回归分析，调整年龄、性别和吸烟因素。
与对照组相比，患者中两种单倍型（rs2745557、rs5277、rs2066826、rs4648261、rs4648262、rs2206593、rs5275 分别为 GGAGGGT 和 GCGGGGT）更为常见（P < 0.024），尽管在所研究的 7 个单核苷酸多态性中未发现个体统计学意义上的显著关联。
我们的研究结果表明，我们在 COX-2 基因中研究的个体多态性与胰腺癌风险无关。然而，与 2 种单倍型存在轻微关联的发现可能与小效应一致，如果有更多的样本，也可能在基因型水平上观察到。
